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Alistair Bailey
I am a researcher at the Centre for Proteomic Research and Cancer Sciences Unit at the University of Southampton. My research interests are in antigen processing and presentation by class I MHC molecules, data science and proteomics.The project I currently work on aims to improve immunotherapy treatment for cancer patients. I also contribute to research into the role of MHC molecules in skin sensitization to chemical allergens, and contagious cancer in the Tasmanian Devil. I am also a Data and Software Carpentry instructor.
Education
Machine Learning
Stanford University
Coursera
2016 - 2016
- 10 week online introduction to machine learning.
Data Science Specialization
John Hopkins University
Coursera
2015 - 2015
- 12 month online set of courses on data science using R, git and command line tools.
PhD, Immunology
Cancer Sciences, University of Southampton
Southampton, UK
2013 - 2008
- Thesis: Relating the structure, function and dynamics of the MHC Class I antigen presenting molecule.
BEng, Civil Engineering
University of Southampton
Southampton, UK
2008 - 2005
- First Class Honours in Civil Engineering.
Engineering, Science & Mathematics Foundation Year
University of Southampton
Southampton, UK
2005 - 2004
- Maths and physics foundation year preparation for undergraduate study.
BTEC ND Audio-Visual Production
Bournemouth & Poole College of Art & Design
Bournemouth, UK
1994 - 1992
- Foundation course in film, photography, TV and radio production.
Research Experience
Research Fellow
Centre for Proteomic Research/Cancer Sciences, University of Southampton
Southampton, UK
Current - 2018
- Cancer Research UK Accelerator: this project aims to identify potential treatment targets for hard to treat cancers such as lung cancer using peptidomics methods.
- We have also developed our method to identify treatment targets for infectious diseases such as influenza.
- In 2020 I also worked to develop a COVID19 test using proteomics methods.
Research Fellow
Centre for Proteomic Research/Cancer Sciences, University of Southampton
Southampton, UK
2018 - 2015
- Developed peptidomics methodology at the UoS for research into the role of MHC molecules in skin sensitisation to chemical allergy.
Research Fellow
Cancer Sciences, University of Southampton
Southampton, UK
2015 - 2013
- MRC Centenary Fellow
Industry Experience
I have worked in a variety of roles ranging from engineering to research scientist. I like collaborative environments where I can learn from my peers.
Internship
Microsoft Research
Cambridge, UK
2012 - 2012
- Helped develop computational model of MHC I peptide selection.
Freelance Satellite Communications Engineer
Globecast
London, UK
2012 - 2004
- I continued to work as an engineer in broadcast TV from 2004 and 2012 on major events such as the Olympics and Football World Cup.
Satellite Communications Engineer
Globecast
London, UK
2004 - 2000
- Full time engineer working in global broadcast TV primarily on sports, news and live entertainment events.
Film and television post-production engineer
Telecine
London, UK
2000 - 1995
- I trained as an engineer to operate various TV & film post-production equipment.
Teaching Experience
I am passionate about teaching foundational coding and data science skills to researchers.
Coding Together
University of Southampton
Southampton, UK
2020 - 2019
- I created and taught an eight week series of collaborative workshops to teach foundational R coding and data science skills based on Carpentries materials.
Software Carpentry
Umeå University
Umeå, Sweden
2018 - 2018
- Taught R for Reproducible Research and assisted in Command Line Basics.
British Society for Proteomics 2018 Data Science Workshop
University of Bradford
Bradford, UK
2018 - 2018
- I created and taught a proteomics data science workshop including introduction to R, Volcano plots, heatmaps and peptide logos.
Data Carpentry
University of Southampton
Southampton, UK
2017 - 2017
- Taught R for Reproducible Research and assisted in Command Line Basics and git.
Data Carpentry
University of Southampton
Southampton, UK
2017 - 2017
- Taught R for Reproducible Research and assisted in introduction to SQL.
Software Carpentry
University of Southampton
Southampton, UK
2017 - 2017
- Assisted with python and git for reproducible research.
Publications
Characterization of the Class I MHC Peptidome Resulting From DNCB Exposure of HaCaT Cells
Toxicological Sciences
N/A
2021 - 2021
- Alistair Bailey, Ben Nicholas, Rachel Darley, Erika Parkinson, Ying Teo, Maja Aleksic, Gavin Maxwell, Tim Elliott, Michael Ardern-Jones, Paul Skipp.
Immunopeptidomic analysis of influenza A virus infected human tissues identifies internal proteins as a rich source of HLA ligands
bioaRxiv
N/A
2021 - 2021
- Ben Nicholas, Alistair Bailey, Karl J. Staples, Tom Wilkinson, Tim Elliott, Paul Skipp.
The immunopeptidomes of two transmissible cancers and their host have a common, dominant peptide motif
Immunology
N/A
2021 - 2021
- Annalisa Gastaldello, Sri H. Ramarathinam, Alistair Bailey, Rachel Owen, Steven Turner, N. Kontouli, Tim Elliott, Paul Skipp, Anthony W. Purcell, Hannah V. Siddle.
Dynamically Driven Allostery in MHC Proteins: Peptide-Dependent Tuning of Class I MHC Global Flexibility
Frontiers in Immunology
N/A
2019 - 2019
- Cory M. Ayres, Esam T. Abualrous, Alistair Bailey, Christian Abraham, Lance M. Hellman, Steven A. Corcelli, Frank Noé, Tim Elliott, Brian M. Baker.
Direct evidence for conformational dynamics in major histocompatibility complex class I molecules
JBC
N/A
2017 - 2017
- Andy van Hateren, Malcolm Anderson, Alistair Bailey, Jörn M. Werner, Paul Skipp, Tim Elliott.
Recent advances in Major Histocompatibility Complex class I antigen presentation: Plastic MHC molecules and TAPBPR mediated quality control
F1000 Research
N/A
2017 - 2017
- Andy van Hateren, Alistair Bailey, Tim Elliott.
Two Polymorphisms Facilitate Differences in Plasticity between Two Chicken Major Histocompatibility Complex Class I Proteins
PLoS One
N/A
2014 - 2014
- Alistair Bailey, Andy van Hateren, Tim Elliott, Jörn M. Werner.
A Mechanistic Basis for the Co-evolution of Chicken Tapasin and Major Histocompatibility Complex Class I Proteins
JBC
N/A
2013 - 2013
- Andy van Hateren, Rachel Carter, Alistair Bailey, Nasia Kontouli, Anthony P. Williams, Jim Kaufman, Tim Elliott.
The cell biology of major histocompatibility complex class I assembly: towards a molecular understanding
Tissue Antigens
N/A
2010 - 2010
- A. Van Hateren, E. James, A. Bailey, A. Phillips, N. Dalchau, T. Elliott